SREBP1 (SREBF1) Rabbit Polyclonal Antibody

CAT#: TA349060

Rabbit Polyclonal Anti-SREBF2 Antibody

Product Images

Western blot analysis of SREBF2 in PC-3 cell lysate with SREBF1 antibody at 1 ug/mL.

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  Immunohistochemistry of SREBF2 in human spleen tissue with SREBF2 antibody at 5 ug/mL.

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  Immunofluorescence of SREBF2 in human spleen tissue with SREBF2 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: SREBF2 antibody was raised against a 15 amino acid peptide near the center of human SREBF2.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: SREBF2 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 126 kDa; Observed: 128 kDa
• Gene Name: sterol regulatory element binding transcription factor 1
• Database Link:
  NP_004167
  Entrez Gene 20787 MouseEntrez Gene 6720 Human
  UniProt ID P36956
• Background: The sterol regulatory element binding transcription factor 2 (SREBF2) is a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis (1,2). The related protein SREBF1 also binds SRE1 and activates transcription in an additive fashion to SREBF2 (2). SREBF2 has been more closely associated with cholesterol synthesis and accumulation, while the SREBF1 proteins are important in the regulation of genes involved in lipid metabolism (3).
• Synonyms: bHLHd1; SREBP-1c; SREBP1; SREBP1a

Reference Data

• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Insulin signaling pathway