WSB1 Rabbit Polyclonal Antibody

CAT#: TA349080

Rabbit Polyclonal Anti-NOX1 Antibody

Product Images

Western blot analysis of NOX1 in 293 cell lysate with NOX1 antibody at 1 ug/mL.

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  Immunohistochemistry of NOX1 in human kidney tissue with NOX1 antibody at 5 ug/mL.

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  Immunofluorescence of NOX1 in human kidney tissue with NOX1 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: NOX1 antibody was raised against a 15 amino acid peptide near the center of human NOX1.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: NOX1 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 62 kDa; Observed: 64 kDa
• Gene Name: WD repeat and SOCS box containing 1
• Database Link:
  NP_599027
  Entrez Gene 26118 Human
  UniProt ID Q9Y6I7
• Background: Voltage-gated proton (hydrogen) channels play an important role in cellular defense against acidic stress (1). NOX1 is a homolog of the catalytic subunit of the superoxide-generating NADPH oxidase of phagocytes, gp91phox (1). Three splice variants of NOX1 have been identified, NOH-1L, NOH-1S and NOH-1Lv (2). NOH-1S is a voltage-gated proton channel that participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain (1-3). NOX1 have the potential to be effective treatments for a range of ischemic diseases (4).
• Synonyms: SWIP1; WSB-1

Reference Data

• Protein Families: Druggable Genome