ATG4C Rabbit Polyclonal Antibody

CAT#: TA349133

Rabbit Polyclonal Anti-ATG4D Antibody

Product Images

Western blot analysis of ATG4D in human testis tissue lysate with ATG4D antibody at (A) 1 and (B) 2 ug/mL.

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  Immunohistochemistry of ATG4D in human testis tissue with ATG4D antibody at 5 ug/mL.

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  Immunofluorescence of ATG4D in human testis tissue with ATG4D antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: ATG4D antibody was raised against a 17 amino acid peptide near the amino terminus of human ATG4D.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: ATG4D antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 52 kDa; Observed: 49 kDa
• Gene Name: autophagy related 4C cysteine peptidase
• Database Link:
  NP_835739
  Entrez Gene 242557 MouseEntrez Gene 313391 RatEntrez Gene 84938 Human
  UniProt ID Q96DT6
• Background: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components (1,2). ATG4D, also known as AUTL4, is one of four mammalian orthologs of the yeast ATG4 protein; all four are cysteine proteases (3). ATG4 is required for ATG8 conjugation to phosphatidylethanolamine on autophagosomal membranes. In mammals, each ATG4 homolog shows a selective preference for the ATG8 homologs (4).
• Synonyms: APG4-C; APG4C; AUTL1; AUTL3

Reference Data

• Protein Families: Protease
• Protein Pathways: Regulation of autophagy