MAGEA4 Rabbit Polyclonal Antibody

CAT#: TA349134

Rabbit Polyclonal Anti-TAU Antibody

Product Images

Immunohistochemistry of TAU in mouse brain tissue with TAU antibody at 5 ug/ml.

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: WB: 1 - 2 ug/mL, IHC: 5 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: TAU antibody was raised against a 19 amino acid peptide near the amino terminus of human TAU.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: TAU antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 83 kDa; Observed: 90 kDa
• Gene Name: MAGE family member A4
• Database Link:
  NP_002353
  Entrez Gene 17140 MouseEntrez Gene 689858 RatEntrez Gene 4103 Human
  UniProt ID P43358
• Background: The microtubial-associated protein TAU (MAPT), more commonly known as TAU, is is normally a highly soluble protein found predominantly in neurons (1), but accumulations of highly phosphorylated tau protein aggregates are observed in several neurodegenerative diseases including Alzheimer?? disease, progressive supranuclear palsy, corticobasal degeneration, and frontotemporal lobar dementia. It was thought that these pathological tau aggregates were the toxic form of tau, but recent studies indicate that soluble and highly phosphorylated tau species are more closely associated with synaptic dysfunction and cell loss (2,3). Mutations in the TAU gene have also been associated with several of these neurodegenerative diseases (4).
• Synonyms: CT1.4; MAGE-41; MAGE-X2; MAGE4; MAGE4A; MAGE4B