WSB1 Rabbit Polyclonal Antibody

CAT#: TA349166

Rabbit Polyclonal Anti-WSB1 Antibody

Product Images

Western blot analysis of WSB1 in human colon tissue lysate with WSB1 antibody at 1 ug/mL.

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  Immunohistochemistry of WSB1 in human colon tissue with WSB1 antibody at 5 ug/mL.

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  Immunofluorescence of WSB1 in human colon tissue with WSB1 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: WSB1 antibody was raised against a 16 amino acid peptide near the amino terminus of human WSB1.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: WSB1 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 46 kDa; Observed: 46 kDa
• Gene Name: WD repeat and SOCS box containing 1
• Database Link:
  NP_056441
  Entrez Gene 26118 Human
  UniProt ID Q9Y6I7
• Background: The WD repeat and SOCS box-containing 1 (WSB1, also known as SWIP1), is a member of the WD-protein subfamily (1). It contains six WD-repeats spanning most of the protein and an SOCS box in the C-terminus and expressed as multiple alternatively spliced isoforms (1,2). WSB1 is thought to function as part of an SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as DIO2 (3). Overexpression of WSB1 is implicated in pancreatic cancer progression, suggesting a role for WSB1 in carcinogenesis (4,5).
• Synonyms: SWIP1; WSB-1

Reference Data

• Protein Families: Druggable Genome