RICTOR Rabbit Polyclonal Antibody

CAT#: TA349591

Rabbit Polyclonal Anti-RICTOR Antibody

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 25-200
  Positive control: Human thyroid cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein of human RICTOR
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: RPTOR independent companion of MTOR complex 2
• Database Link:
  NP_689969
  Entrez Gene 78757 MouseEntrez Gene 253260 Human
  UniProt ID Q6R327
• Background: Rapamycin-insensitive companion of mTOR is a protein that in humans is encoded by the RICTOR gene. RICTOR and MTOR are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth. Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors.
• Synonyms: AVO3; hAVO3; PIA

Reference Data

• Protein Pathways: mTOR signaling pathway