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CARD8 Rabbit Polyclonal Antibody
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Other products for "CARD8"
Specifications
| Product Data | |
| Applications | IHC |
| Recommended Dilution | IHC: 25-100 Positive control: Human thyroid cancer Predicted cell location: Nucleus and Cytoplasm |
| Reactivities | Human |
| Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Fusion protein of human CARD8 |
| Formulation | pH7.4 PBS, 0.05% NaN3, 40% Glyceroln |
| Concentration | lot specific |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Gene Name | caspase recruitment domain family member 8 |
| Database Link | |
| Background | The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. |
| Synonyms | CARDINAL; DACAR; DAKAR; NDPP; NDPP1; TUCAN |
| Reference Data | |
| Protein Families | Druggable Genome |
| Protein Pathways | NOD-like receptor signaling pathway |
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complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.