Corticotropin Releasing Factor (CRH) Rabbit Polyclonal Antibody

CAT#: TA350642

Rabbit Polyclonal Anti-CRH Antibody

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 200-1000
  WB positive control: Human placenta tissue
  IHC: 25-100
  Positive control: Human cervical cancer
  Predicted cell location: Cytoplasm or Nucleus
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide of human CRH
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 21 kDa
• Gene Name: corticotropin releasing hormone
• Database Link:
  NP_000747
  Entrez Gene 12918 MouseEntrez Gene 81648 RatEntrez Gene 1392 Human
  UniProt ID P06850
• Background: Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery.
• Synonyms: CRF; CRH1

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Long-term depression