Snf1lk (SIK1) Rabbit Polyclonal Antibody

CAT#: TA351732

Rabbit Polyclonal Anti-SIK1 Antibody

Product Images

Gel: 6%SDS-PAGE Lysate: 40 μg Lane 1-5: HT29 cells hela cells mouse liver tissue A549 cells Jurkat cells Primary antibody: TA351732 (SIK1 Antibody) at dilution 1/250 Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 10 seconds

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  Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using TA351732 (SIK1 Antibody) at dilution 1/40 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using TA351732 (SIK1 Antibody) at dilution 1/40, treated with synthetic peptide. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 500-2000
  WB positive control: Human colon sigmoideum cancer and colon cancer tissue, mouse lung and human normal colon tissue, lovo and hela cells
  IHC: 25-100
  Positive control: Human tonsil
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide of human SIK1
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 85 kDa
• Gene Name: salt inducible kinase 1
• Database Link:
  NP_775490
  Entrez Gene 17691 MouseEntrez Gene 59329 RatEntrez Gene 150094 Human
• Background: SIK1 (salt-inducible kinase 1), also known as SNF1LK or MSK, is a 783 amino acid protein that contains one UBA domain and one protein kinase domain and belongs to the Ser/Thr protein kinase family. Localized to both the nucleus and the cytoplasm, SIK1 uses magnesium as a cofactor to catalyze the ATP-dependent phosphorylation of target proteins and is thought to be important for the early stages of skeletal muscle growth and myocardial cell differentiation. Additionally, SIK1 has a potential role in regulation of the G2/M cell cycle transition, as well as in inhibitory control of CREB protein function.
• Synonyms: MSK; SIK; SNF1LK

Reference Data

• Protein Families: Druggable Genome, Protein Kinase