CD51 (ITGAV) Rat Monoclonal Antibody [Clone ID: AvB6 53a.2]

CAT#: TA352872L

Rat monoclonal Anti-Integrin aVb6 Clone AvB6 53a.2

Specifications

Product Data

• Clone Name: AvB6 53a.2
• Recommended Dilution: FACS ; IF ; Functional
• Reactivities: Human
• Host: Rat
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Mouse fibroblasts retrovirally infected with cDNA to human beta6 (3T3b6.19). Cells expressed a mouse/human avb6 chimera.
• Formulation: PBS with 0.02% Sodium Azide
• Concentration: lot specific
• Purification: Purified by affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: integrin subunit alpha V
• Database Link:
  NP_002201
  Entrez Gene 3685 Human
  UniProt ID P06756
• Background: Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha-v beta-6 is upregulated in cancers and during tissue remodelling but is absent from resting adult tissues. Integrin alpha-v beta-6 promotes invasion and correlates with poor survival and therefore makes a promising therapeutic target.
• Synonyms: CD51; MSK8; VNRA; VTNR
• Note: Recommended Concentration: 10ug/ml

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Cell adhesion molecules (CAMs), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hypertrophic cardiomyopathy (HCM), Pathways in cancer, Regulation of actin cytoskeleton, Small cell lung cancer