CD51 (ITGAV) Rat Monoclonal Antibody [Clone ID: Avβ6 62ow.17]

CAT#: TA352873L

Rat monoclonal Anti-Integrin aVβ6 Clone Avβ6 62ow.17

Specifications

Product Data

• Clone Name: Avβ6 62ow.17
• Recommended Dilution: IHC ; WB
• Reactivities: Human
• Host: Rat
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Mouse fibroblasts retrovirally infected with cDNA to human beta6 (3T3β6.19). Cells expressed a mouse/human avβ6 chimera.
• Formulation: PBS with 0.02% Sodium Azide
• Concentration: lot specific
• Purification: Purified by affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: integrin subunit alpha V
• Database Link:
  NP_002201
  Entrez Gene 3685 Human
  UniProt ID P06756
• Background: Alpha-v beta-6 is upregulated on cancers and during tissue remodelling but is weak absent on resting adult tissues. It promotes invasion and correlates with poor survival. It is likely to be good therapeutic target.
• Synonyms: CD51; MSK8; VNRA; VTNR
• Note: Does not recognise mouse avβ6

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Cell adhesion molecules (CAMs), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hypertrophic cardiomyopathy (HCM), Pathways in cancer, Regulation of actin cytoskeleton, Small cell lung cancer