Factor VIII (F8) Mouse Monoclonal Antibody [Clone ID: RFF-VIII:c/8]

CAT#: TA353177L

Mouse monoclonal Anti-Factor VIII Clone RFF-VIII:c/8

Specifications

Product Data

• Clone Name: RFF-VIII:c/8
• Recommended Dilution: IF ; Functional ; WB
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1, kappa
• Clonality: Monoclonal
• Immunogen: Purified human factor VIII
• Formulation: PBS with 0.02% Sodium Azide
• Concentration: lot specific
• Purification: Purified by affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: coagulation factor VIII
• Database Link:
  NP_063916
  Entrez Gene 2157 Human
  UniProt ID P00451
• Background: The commonest severe congenital bleeding disorder in all races is haemophilia A. The characteristic defect is a lack of coagulation factor VIII:C. Factor VIII:C is a glycoprotein that functions as a cofactor for factor IXa which, in the presence of calcium and phospholipids, converts factor X to the activated form Xa. This antibody binds to human FVIII:C heavy chain and inhibits its function.
• Synonyms: AHF; DXS1253E; F8B; F8C; FVIII; HEMA

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Complement and coagulation cascades