RACGAP1 Rabbit Polyclonal Antibody

CAT#: TA353413L

Rabbit polyclonal anti-pS157 HsCyk-4 (MgcRacGAP and RacGAP1) antibody

Specifications

Product Data

• Recommended Dilution: IF ; IP ; WB
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: pS157 HsCyk-4 (MgcRacGAP and RacGAP1)
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: Rac GTPase activating protein 1
• Database Link:
  NP_037409
  Entrez Gene 26934 MouseEntrez Gene 315298 RatEntrez Gene 29127 Human
  UniProt ID Q9H0H5
• Background: HsCyk-4 (or MgcRacGAP) is a subunit of the centralspindlin, and contains a GTPase activator protein (GAP) domain and directly interacts with the GTP exchange factor (GEF) Ect2, and both HsCyk-4 and Ect2 are essential for equatorial recruitment of the RhoA GTPase, the master regulator of actomyosin dynamics during cytokinesis. Plk1 binds and directly phosphorylates the HsCyk-4.
• Synonyms: CYK4; HsCYK-4; ID-GAP; MgcRacGAP
• Note: The immunogen is 100% conserved from human to mouse to rat; and the phosphorylation of Ser157 has been shown in human cells but not in mouse and rat.

Reference Data

• Protein Families: Druggable Genome