Nav1.5 (SCN5A) Mouse Monoclonal Antibody [Clone ID: 4G8:1G7]

CAT#: TA353459L

Mouse monoclonal Anti-Nav 1.5 Clone 4G8:1G7

Product Images

Two colour Immunocytochemistry on Nav1.5 overexpressing 293 cells (150uL per slide): A. Anti-nNav 1.5 [4G8:1G7], B. DAPI

Specifications

Product Data

• Clone Name: 4G8:1G7
• Applications: IF
• Recommended Dilution: FACS ; IF ; IHC ; WB
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Peptide (14mer) from an extracellular domain of Nav1.5
• Formulation: PBS with 0.02% Sodium Azide
• Concentration: lot specific
• Purification: Purified by affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 180-200
• Gene Name: sodium voltage-gated channel alpha subunit 5
• Database Link:
  NP_000326
  Entrez Gene 6331 Human
  UniProt ID Q14524
• Background: Voltage-gated sodium channesl (VGSCs) mediate regenerative cell membrane depolarization and conduction of electrical signalling in nerves and muscles. They have also been detected in lymphocytes, glia, and fibroblasts. VGSC proteins are comprised of a core alpha-subunit, together with one or more additional regulatoy beta-subunit. VCSC expression has been detected in a number of tumour cell lines and has been implicated in the metastatic behaviour of breast and prostate cancer cells. Na(v)1.5, the major cardiac voltage-gated Na(+) channel, plays a central role in the generation of the cardiac action potential and in the propagation of electrical impulses in the heart. Its importance for normal heart function has been recently exemplified by reports of numerous mutations found in the gene SCN5A which encodes Na(v)1.5.
• Synonyms: CDCD2; CMD1E; CMPD2; HB1; HB2; HBBD; HH1; ICCD; IVF; LQT3; Nav1.5; PFHB1; SSS1; VF1
• Note: 4G8:1G7 is recommended for Western blotting and Immunocytochemistry using 2ug/ml and 10ug/ml, respectively.

Reference Data

• Protein Families: Druggable Genome, Ion Channels: Sodium, Transmembrane