SNAIL (SNAI1) Mouse Monoclonal Antibody [Clone ID: 20C8]

CAT#: TA353467L

Mouse monoclonal Anti-SNAIL1 Clone 20C8

Specifications

Product Data

• Clone Name: 20C8
• Recommended Dilution: ELISA ; IHC ; IF ; IP ; WB
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Human Snail 1 recombinant protein
• Concentration: lot specific
• Purification: Purified by affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: snail family transcriptional repressor 1
• Database Link:
  NP_005976
  Entrez Gene 6615 Human
  UniProt ID O95863
• Background: The Snail superfamily are zinc finger transcription factors that represses expression of E-cadherin, desmoplakin, muc-1, cytokeratin18 while enhances expression of vimentin and fibronectin (all events associated to EMT). Snail1 overexpression leads to epithelial-mesenchymal transition (EMT) and has a strong association with metastatic disease:â?¢Snail expression has been detected in various cancer indications - any carcinoma.â?¢Over expression of Snail 1 in epithelial cells produces an invasive phenotype, in vitro and in vivo â?¢Examination of biopsies of invasive breast tumours have shown that all primary tumours that had lymph node metastases expressed Snail
• Synonyms: dJ710H13.1; SLUGH2; SNA; SNAH; SNAIL; SNAIL1

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Adherens junction