PPAR delta (PPARD) Rabbit Polyclonal Antibody

CAT#: TA354466

Rabbit anti PPARb Polyclonal Antibody

Product Images

WB: Whole cell lysate derived from HT-29 was resolved onto 10% SDS-PAGE, transferred onto NC membrane, then immune-probed by Rabbit anti-PPAR-beta antibody (Lane 1) or pre-depleted antibody by the immunizing antigen (lane 2) at 1:500. The immune-reactive band around ~50kDa was abolished.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The full-length recombinant protein of human PPAR-beta.
• Formulation: This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
• Purification: The Rabbit IgG is purified by Epitope Affinity Purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: ~50 kDa
• Gene Name: peroxisome proliferator activated receptor delta
• Database Link:
  NP_001165289
  Entrez Gene 5467 Human
  UniProt ID Q03181
• Background: The Peroxisome proliferator-activated receptor beta (PPAR-beta) is a ligand activated transcription factor belonging to the nuclear receptor superfamily. PPARs bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. The PPAR-beta is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of PPAR-beta is found to be elevated in colorectal cancer cells.
• Synonyms: FAAR; NR1C2; NUC1; NUCI; NUCII; PPARB

Reference Data

• Protein Families: Druggable Genome, Nuclear Hormone Receptor, Transcription Factors
• Protein Pathways: Acute myeloid leukemia, Pathways in cancer, PPAR signaling pathway, Wnt signaling pathway