ZBTB4 Rabbit Polyclonal Antibody

CAT#: TA354895

Rabbit anti ZBTB4-CT Polyclonal Antibody

Product Images

WB: The whole mouse brain tissue lysates were immunoblotted by Rabbit anti-ZBTB4 (CT) at 1:500 (Lane 1). The immunoreactive band is blocked by pre-incubation of immunizing peptide (lane 2)

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
• Reactivities: Bovine, Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthetic peptide corresponding to the C-terminus of human ZBTB4 protein. This sequence is identical to human, mouse, rat, etc.
• Formulation: This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
• Purification: The Rabbit IgG is purified by Epitope Affinity Purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 105 kDa
• Gene Name: zinc finger and BTB domain containing 4
• Database Link:
  NP_001122305
  Entrez Gene 75580 MouseEntrez Gene 287441 RatEntrez Gene 57659 Human
  UniProt ID Q9P1Z0
• Background: Zink finger and BTB domain coating 4 (ZBTB4) is a transcriptional repressor protein, which is associated with the Sin3/histone deacetylase co-repressor and represses expression of P21CIP1 as part of a heterodimeric complex with Miz1. In vivo, expression of ZBTB4 is downregulated in advanced stages of multiple human tumours. In cell culture, depletion of ZBTB4 promotes cell cycle arrest in response to activation of p53 and suppresses apoptosis through regulation of P21CIP1, thereby promoting long-term cell survival. ZBTB4 is a critical determinant of the cellular response to p53 activation and reinforce the notion that p21Cip1 can provide an essential survival signal in cells with activated p53.
• Synonyms: KAISO-L1; ZNF903