Zinc transporter 8 (SLC30A8) Rabbit Polyclonal Antibody

CAT#: TA355018

Rabbit Polyclonal Anti-SLC30A8 Antibody

Product Images

Western blot analysis of SLC30A8 in human pancreas tissue lysate with SLC30A8 antibody at 1ug/ml in (A) the absence and (B) the presence of blocking peptide

• 

  Immunohistochemistry of SLC30A8 in human pancreas tissue with SLC30A8 Antibody at 5ug/ml.

• 

  Immunofluorescence of SLC30A8 in human pancreas tissue with SLC30A8 Antibody at 20ug/ml.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1-2µg/mL.
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: SLC30A8 antibody was raised against a peptide corresponding to 14 amino acids near the amino terminus of human SLC30A8.
• Formulation: SLC30A8 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: SLC30A8 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 35, 41 kDa; Observed: 35, 41 kDa
• Gene Name: solute carrier family 30 member 8
• Database Link:
  NP_776250
  Entrez Gene 169026 Human
  UniProt ID Q8IWU4
• Background: SLC30A8 Antibody: SLC30A8 is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles and is expressed at a high level in the pancreas, particularly in islets of Langerhans, and co-localizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells (1). Allelic variants of SLC30A8 have been identified as major genetic risk factors for the development of Type 2 diabetes (2), but no genetic association has been found with Type 1 diabetes (3). SLC30A8 expression in ?-cells was found to be influenced by cytokine expression, particularly IFN-gamma and IL-1beta (4).
• Synonyms: ZnT-8; ZNT8
• Note: SLC30A8 antibody can be used for Western blot at 1 - 2 µg/mL.

Reference Data

• Protein Families: Transmembrane