MSH2 Mouse Monoclonal Antibody [Clone ID: 79H11]

CAT#: TA355274

Mismatch Repair Protein (MSH2) Mouse Monoclonal Antibody

Specifications

Product Data

• Clone Name: 79H11
• Applications: IHC
• Recommended Dilution: 1:80
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Prokaryotic recombinant protein corresponding to a 304 amino acid region of the N-terminus of the human MSH2 molecule
• Specificity: Human MSH2
• Formulation: Liquid tissue culture supernatant containing sodium azide as a preservative
• Conjugation: Unconjugated
• Storage: Store at 2-8°C
• Stability: 12 months
• Gene Name: mutS homolog 2
• Database Link:
  Entrez Gene 4436 Human
• Background: Human mismatch repair protein 2 (MSH2) is involved in the initial recognition of mismatched nucleotides during the post replication mismatch repair process. Therefore, the loss of MSH2 function leads to the accumulation of replication errors, which in turn may be responsible for the multiple mutations required for multistage carcinogenesis. MSH2 is reported to be expressed in the nuclei of cells from a variety of tissues including thyroid, heart, smooth muscle and the germinal centers of lymphoid follicles. In ileum and colon, MSH2 expression has been reported in the crypts, the cells which are undergoing rapid renewal. They are responsible for the continuous production of differentiated cells which migrate over 2 to 4 days before being sloughed into the lumen.
• Synonyms: COCA1; FCC1; HNPCC; HNPCC1; LCFS2