Perforin (PRF1) Mouse Monoclonal Antibody [Clone ID: 5B10]

CAT#: TA355333

Perforin Mouse Monoclonal Antibody


USD 1,595.00

3 Weeks*

Size
    • 1 ml

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Specifications

Product Data
Clone Name 5B10
Applications IHC
Recommended Dilution 1:20
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Recombinant prokaryotic protein corresponding to an external region of the C-terminus of the perforin molecule
Specificity Human perforin. Shows cross-reactivity with smooth muscle and differentiated epithelium
Formulation Liquid tissue culture supernatant containing sodium azide as a preservative
Conjugation Unconjugated
Storage Store at 2-8°C
Stability 12 months
Gene Name perforin 1
Background Perforin is a pore-forming protein found in cytoplasmic granules of cytotoxic T-lymphocytes (CTLs). CTLs bind to cells which express foreign antigens and induce them to lyze. Perforin forms circular lesions on the target cell membrane similar to those induced by complement. Perforin and C9 share a high degree of homology particularly at the membrane spanning region. Perforin is reported to be constitutively expressed in human CD3 negative, CD56 positive NK cells, CD3 positive large granular lymphocytes and gamma/delta T cells. This expression is significantly induced in CD8 positive T cells but to a lesser extent in gamma/delta T cells and NK cells. The induction of perforin mRNA is partially blocked by the immunosuppressive drug cyclosporin A.
Synonyms cytolysin; FLH2; HPLH2; MGC65093; OTTHUMP00000019759; P1; PFN1; PFP
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.