Wilms Tumor Protein (WT1) Mouse Monoclonal Antibody [Clone ID: WT49]
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Specifications
Product Data | |
Clone Name | WT49 |
Applications | IHC |
Recommended Dilution | 1:100 |
Reactivities | Human |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | A prokaryotic recombinant protein containing 1–181 amino acids of the N-terminal of the Wilms’ Tumor protein |
Specificity | Human Wilms’ Tumor WT1 gene product |
Formulation | Liquid tissue culture supernatant containing sodium azide as a preservative |
Conjugation | Unconjugated |
Storage | Store at 2-8°C |
Stability | 12 months |
Gene Name | Wilms tumor 1 |
Database Link | |
Background | Wilms' tumor protein (WT1) has a role in transcriptional regulation and is expressed in the kidney and a subset of hematopoietic cells. Alteration of transcription factor function is a common mechanism in oncogenesis. The WT1 protein contains a DNA binding domain and any deletions or point mutations of the WT1 gene which destroy this activity result in the development of the childhood nephroblastoma Wilms' tumor and Denys-Drash syndrome. The description of WT1 involvement in nephroblastoma is not clear. |
Synonyms | AWT1; GUD; OTTHUMP00000037553; WAGR; WIT-2; WT33 |
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