PITX2 Rabbit Polyclonal Antibody

CAT#: TA355956

PITX2 Antibody - N-terminal region

Product Images

WB Suggested Anti-PITX2 Antibody Titration: 1.0 ug/ml Positive Control: HT1080 Whole Cell

Specifications

Product Data

• Applications: WB
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: Expected reactivity: Human, Mouse, Pig, Rabbit, Rat
  Homology: Human: 100%; Mouse: 92%; Pig: 92%; Rabbit: 92%; Rat: 92%
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted Protein Size: 36kDa
• Gene Name: paired like homeodomain 2
• Database Link:
  NP_000316
  Entrez Gene 5308 Human
  UniProt ID Q99697-2
• Background: This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described.
• Synonyms: ARP1; Brx1; IDG2; IGDS; IGDS2; IHG2; IRID2; MGC20144; MGC111022; Otlx2; OTTHUMP00000163736; PTX2; RGS; RIEG; RIEG1; RS; Solurshin

Reference Data

• Protein Families: Transcription Factors
• Protein Pathways: TGF-beta signaling pathway