CD130 (IL6ST) Rabbit Polyclonal Antibody

CAT#: TA358385

IL6ST Antibody - middle region

Product Images

WB Suggested Anti-IL6ST Antibody Titration: 1.0 ug/ml Positive Control: MDA-MB-435S Whole Cell

• 

  Host: Rabbit Target: IL6ST Positive control (+): Mouse Kidney (M-KI) Negative control (-): Mouse Small Intestine (M-IN) Antibody concentration: 1ug/ml

• 

  Rabbit Anti-IL6ST Antibody Catalog Number: TA358385 Formalin Fixed Paraffin Embedded Tissue: Human Thyroid Tissue Observed Staining: Plasma membrane and cytoplasm in follicular cells Primary Antibody Concentration: 1:100 Other Working Concentrations: 1:600 Secondary Antibody: Donkey anti-Rabbit-Cy3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0.5 - 2.0 sec

• 

  Rabbit Anti-IL6ST Antibody Catalog Number: TA358385 Formalin Fixed Paraffin Embedded Tissue: Human heart Tissue Observed Staining: Plasma membrane Primary Antibody Concentration: 1:100 Other Working Concentrations: N/A Secondary Antibody: Donkey anti-Rabbit-Cy3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0.5 - 2.0 sec

Specifications

Product Data

• Applications: IHC, WB
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: Expected reactivity: Cow, Dog, Guinea Pig, Horse, Human, Rabbit, Rat
  Homology: Cow: 93%; Dog: 93%; Guinea Pig: 86%; Horse: 86%; Human: 100%; Rabbit: 77%; Rat: 86%
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted Protein Size: 35kDa
• Gene Name: interleukin 6 signal transducer
• Database Link:
  NP_786943
  Entrez Gene 3572 Human
  UniProt ID P40189-2
• Background: The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis.
• Synonyms: CD130; CDw130; GP130; GP130-RAPS; IL-6R-beta; IL6R-beta; OTTHUMP00000122545

Reference Data

• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway