NKG2D (KLRK1) Rabbit Polyclonal Antibody

CAT#: TA358392

KLRK1 Antibody - C-terminal region

Product Images

WB Suggested Anti-KLRK1 Antibody Titration: 1.0 ug/ml Positive Control: MDA-MB-435S Whole Cell

Specifications

Product Data

• Applications: WB
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: Expected reactivity: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
  Homology: Cow: 79%; Dog: 86%; Guinea Pig: 91%; Horse: 86%; Human: 100%; Mouse: 92%; Rabbit: 86%; Rat: 93%
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted Protein Size: 24kDa
• Gene Name: killer cell lectin like receptor K1
• Database Link:
  NP_031386
  Entrez Gene 22914 Human
  UniProt ID P26718
• Background: Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster.
• Synonyms: CD314; D12S2489E; FLJ17759; FLJ75772; KLR; NKG2-D; NKG2D

Reference Data

• Protein Families: Transmembrane
• Protein Pathways: Natural killer cell mediated cytotoxicity