NLRP3 Rabbit Polyclonal Antibody

CAT#: TA358397

NLRP3 Antibody - N-terminal region

Product Images

WB Suggested Anti-NLRP3 Antibody Titration: 1.0 ug/ml Positive Control: Fetal Kidney

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  Lanes: Lane 1: 30ug human glioma lysate Lane 2: 30ug IL-1 treated human glioma lysate Primary Antibody Dilution: 1:500 Secondary Antibody: Anti-rabbit-HRP Secondary Antibody Dilution: 1:500 Gene Name: NLRP3 Submitted by: Anonymous

Specifications

Product Data

• Applications: WB
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: Expected reactivity: Cow, Dog, Horse, Human, Pig, Rabbit
  Homology: Cow: 93%; Dog: 79%; Horse: 93%; Human: 100%; Pig: 93%; Rabbit: 79%
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted Protein Size: 114kDa
• Gene Name: NLR family, pyrin domain containing 3
• Database Link:
  NP_004886
  Entrez Gene 114548 Human
  UniProt ID Q96P20
• Background: This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID).
• Synonyms: AGTAVPRL; AII; AII/AVP; AVP; C1orf7; CIAS1; CLR1.1; cryopyrin; FCAS; FCU; FLJ95925; MWS; NALP3; PYPAF1

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: NOD-like receptor signaling pathway