SOCS2 Rabbit Polyclonal Antibody

CAT#: TA358429

SOCS2 Antibody - C-terminal region

Product Images

WB Suggested Anti-SOCS2 Antibody Titration: 1.0 ug/ml Positive Control: U937 Whole Cell

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  Lanes: Lane 1: 50ug Mouse adipose lysate Primary Antibody Dilution: 1:1000 Secondary Antibody: Donkey anti-Rabbit-HRP Secondary Antibody Dilution: 1:10000 Gene Name: SOCS2 Submitted by: Libin Liu, Boston University.

Specifications

Product Data

• Applications: WB
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: Expected reactivity: Cow, Dog, Guinea Pig, Human, Mouse, Pig, Rabbit, Rat
  Homology: Cow: 100%; Dog: 100%; Guinea Pig: 93%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted Protein Size: 22kDa
• Gene Name: suppressor of cytokine signaling 2
• Database Link:
  NP_003868
  Entrez Gene 216233 MouseEntrez Gene 8835 Human
  UniProt ID O14508
• Background: This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon (IFN)-gamma. The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling. Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control.
• Synonyms: CIS-2; CIS2; Cish2; SOCS-2; SSI-2; SSI2; STATI2

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Insulin signaling pathway, Jak-STAT signaling pathway, Type II diabetes mellitus