Enkephalin (PENK) Rabbit Polyclonal Antibody

CAT#: TA364075

Rabbit polyclonal anti Met-Enkephalin-Arg-Gly-Leu; purified rabbit IgG

Specifications

Product Data

• Applications: ELISA
• Recommended Dilution: This antibody has been tested and validated in ELISA against Methionine Enkephalin-Arg-Gly-Leu. Other applications like immunohistochemistry (IHC), FACS or Western Blot may work as well. Optimal dilutions should be determined by the end user.
• Reactivities: Human, Mammalian
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide H-Tyr-Gly-Gly-Phe-Met-Arg-Gly-Leu-NH2 coupled to a carrier protein.
• Formulation: Protein A affinity purified from antiserum, lyophilized, packaged under nitrogen. Reconstitute by adding 0.2ml distilled water. This stock solution contains 2mg/ml IgG, phosphate buffer saline pH 7.4 (PBS), and 0.02% (w/v) Thimerosal as a preservative.
• Concentration: N/A
• Conjugation: Unconjugated
• Storage: Original vial: at least one year at 4° - 8°C from date of delivery. Minimize repeated thawing and freezing of the antiserum by freezing aliquots at -20°C or below.
• Gene Name: proenkephalin
• Database Link:
  Entrez Gene 5179 Human
  UniProt ID P01210
• Background: Met-Enkephalin is an endogenous opioid pentapeptide that has opioid effects of a relatively short duration. It is one of the two forms of enkephalin, the other being leu-enkephalin. The enkephalins are considered to be the primary endogenous ligands of the δ-opioid receptor, due to their high potency and selectivity for the site over the other endogenous opioids. Met- enkephalin is found mainly in the adrenal medulla and throughout the central nervous system (CNS). It is synthesized from proenkephalin via proteolytic cleavage. As a result, its cleavage generates: the met-enkephalin derivatives, the heptapeptide met-enkephalin-arg-phe (261– 267), and the octapeptide met-enkephalin-arg-gly-leu (186–193). This antibody was generated by immunization of rabbits with Methionine Enkephalin-Arg-Gly- Leu coupled to a carrier protein.
• Synonyms: preproenkephalin; proenkephalin