MORF4L2 Rabbit Polyclonal Antibody

CAT#: TA368079

MORF4L2 rabbit polyclonal antibody

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 25-100
  Positive control: Human gastric cancer
  Predicted cell location: Nucleus and Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide of human MORF4L2
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C.
• Stability: 1 year
• Database Link:
  UniProt ID Q15014
• Background: The members of the mortality factor family include mortality factor 4 (MORF4), mortality factor 4 like 1 (MORF4L1), also known as MORF4-related gene 15 (MRG15), and mortality factor 4 like 2 (MORF4L2), also known as MORF-4 related gene X (MRGX). The human MORF4 gene maps to chromosome 4q34.1. MORF4 induces a senescent-like phenotype in complementation group B immortal cell lines. The genes encoding MORF4L1 and MORF4L2 map to chromosomes 15q25.1 and Xq22.2, respectively. MORF4, MORF4L1 and MORF4L2 each contain a C-terminal leucine zipper. An association between MORF4L1, Rb (retinoblastoma tumor suppressor) and PAM14 (protein associated with MORF4L1) suggests a role for MORF4L1 in transcription regulation. MORF4L1 also associates with the histone acetyl transferase MOF. In addition, MORF4, MORF4L1 and MORF4L2 interact with mSin3A and TLE (transducin-like enhancer of split). The MORF/mSin3A/TLE association may repress transcription. In Purkinje cells, MORF4L1 localizes to the dendrites and the nuclei.