RNF139 Rabbit Polyclonal Antibody

CAT#: TA371486

RNF139 rabbit polyclonal antibody

Product Images

Immunohistochemistry of paraffin-embedded Human breast cancer tissue using TA371486 (RNF139 Antibody) at dilution 1/35 (Original magnification: ×200)

• 

  Immunohistochemistry of paraffin-embedded Human breast cancer tissue using TA371486 (RNF139 Antibody) at dilution 1/35, treated with synthetic peptide. (Original magnification: ×200)

• 

  Immunohistochemistry of paraffin-embedded Human brain tissue using TA371486 (RNF139 Antibody) at dilution 1/35 (Original magnification: ×200)

• 

  Immunohistochemistry of paraffin-embedded Human brain tissue using TA371486 (RNF139 Antibody) at dilution 1/35, treated with synthetic peptide. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 25-100
  Positive control: Human breast cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide of human RNF139
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C.
• Stability: 1 year
• Gene Name: ring finger protein 139
• Database Link:
  Entrez Gene 11236 Human
  UniProt ID Q8WU17
• Background: The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP.
• Synonyms: HRCA1; MGC31961; RCA1; TRC8