CHM Rabbit Polyclonal Antibody

CAT#: TA372233

CHM rabbit polyclonal antibody

Product Images

Immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using TA372233 (CHM Antibody) at dilution 1/85 (Original magnification: ×200)

• 

  Immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using TA372233 (CHM Antibody) at dilution 1/85, treated with synthetic peptide. (Original magnification: ×200)

• 

  Immunohistochemistry of paraffin-embedded Human gastric cancer tissue using TA372233 (CHM Antibody) at dilution 1/85 (Original magnification: ×200)

• 

  Immunohistochemistry of paraffin-embedded Human gastric cancer tissue using TA372233 (CHM Antibody) at dilution 1/85, treated with synthetic peptide. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 50-200
  Positive control: Human colorectal cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide of human CHM
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C.
• Stability: 1 year
• Gene Name: CHM, Rab escort protein 1
• Database Link:
  Entrez Gene 1121 Human
  UniProt ID P24386
• Background: This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia; also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina. Alternatively spliced transcript variants have been found for this gene.
• Synonyms: choroideremia; DXS540; FLJ38564; GGTA; HSD-32; MGC102710; REP-1; REP1; TCD