SUR1 (ABCC8) Rabbit Polyclonal Antibody

CAT#: TA373140

ABCC8 Rabbit polyclonal Antibody


USD 275.00

3 Weeks*

Size
    • 100 ul

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Specifications

Product Data
Applications WB
Recommended Dilution WB,1:500 - 1:2000
Reactivities Mouse
Modifications Unmodified
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 700-1000 of human ABCC8 (NP_000343.2).
Formulation Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Concentration lot specific
Purification Affinity purification
Conjugation Unconjugated
Storage Store at -20℃. Avoid freeze / thaw cycles.
Stability Shelf life: one year from despatch.
Predicted Protein Size 5kDa/176kDa/177kDa
Gene Name ATP binding cassette subfamily C member 8
Background The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternatively spliced transcript variants have been found for this gene.
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.