ADRM1 Rabbit Monoclonal Antibody [Clone ID: R07-2A8]

CAT#: TA383680

ADRM1 Rabbit monoclonal Antibody

Product Images

Western blot detection of ADRM1 in K562,Hela cell lysates using ADRM1 Rabbit mAb(1:1000 diluted).Predicted band size:42kDa.Observed band size:42kDa.

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  Immunocytochemistry of ADRM1(green) in Hela cells using ADRM1 Rabbit mAb at dilution 1/50, and DAPI(blue)

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  Immunohistochemistry of ADRM1 in paraffin-embedded Human breast cancer tissue using ADRM1 Rabbit mAb at dilution 1/1

Specifications

Product Data

• Clone Name: R07-2A8
• Applications: IF, IHC, IP, WB
• Recommended Dilution: WB: 1/2000-1/10000
  IHC: 1/20
  ICC/IF: 1/20-1/100
  IP: 1/20
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: A synthetic peptide of human ADRM1
• Formulation: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: Calculated MW: 42 kDa; Observed MW: 42 kDa
• Gene Name: adhesion regulating molecule 1
• Database Link:
  Entrez Gene 11047 Human
  UniProt ID Q16186
• Background: Swiss-Prot Acc.Q16186.Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engages and activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation. UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex.
• Synonyms: ARM-1; ARM1; GP110; hRpn13; MGC29536; Rpn13