Annexin A1 (ANXA1) Rabbit Monoclonal Antibody [Clone ID: R08-5A8]

CAT#: TA383724

Annexin A1 Rabbit monoclonal Antibody

Product Images

Western blot detection of Annexin A1 in K562,C6,3T3,Hela cell lysates using Annexin A1 Rabbit mAb(1:1000 diluted).Predicted band size:39kDa.Observed band size:39kDa.

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  Immunohistochemistry of Annexin A1 in paraffin-embedded Human tonsil using Annexin A1 Rabbit mAb at dilution 1/50

Specifications

Product Data

• Clone Name: R08-5A8
• Applications: IF, IHC, IP, WB
• Recommended Dilution: WB: 1/1000
  IHC: 1/500
  ICC/IF: 1/200
  IP: 1/20
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: Recombinant protein of human Annexin A1
• Formulation: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: Calculated MW: 39 kDa; Observed MW: 39 kDa
• Gene Name: annexin A1
• Database Link:
  Entrez Gene 301 Human
  UniProt ID P04083
• Background: Swiss-Prot Acc.P04083.Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response . Promotes resolution of inflammation and wound healing (PubMed:25664854). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca2+ and can bind up to eight Ca2+ ions . Displays Ca2+-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca2+-dependent interaction between phagosomes and the actin cytoskeleton .
• Synonyms: Annexin-1; ANX1; Chromobindin-9; LPC1; OTTHUMP00000021475; p35