ATG4C Rabbit Monoclonal Antibody [Clone ID: R08-8G9]

CAT#: TA383767

ATG4C Rabbit monoclonal Antibody

Product Images

Western blot analysis of ATG4C in K562, Hela lysates using ATG4C antibody.

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  Immunohistochemistry analysis of paraffin-embedded Human lung cancer using ATG4C antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Specifications

Product Data

• Clone Name: R08-8G9
• Applications: IHC, WB
• Recommended Dilution: WB: 1/1000
  IHC: 1/50
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: Recombinant protein of human ATG4C
• Formulation: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: Calculated MW: 53 kDa; Observed MW: 53 kDa
• Gene Name: autophagy related 4C cysteine peptidase
• Database Link:
  Entrez Gene 84938 Human
  UniProt ID Q96DT6
• Background: Swiss-Prot Acc.Q96DT6.Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation . Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.
• Synonyms: APG4-C; APG4C; AUTL1; AUTL3; autophagin-3; FLJ14867