BAG3 Rabbit Monoclonal Antibody [Clone ID: R05-6D5]

CAT#: TA383800

BAG3 Rabbit monoclonal Antibody

Specifications

Product Data

• Clone Name: R05-6D5
• Applications: WB
• Recommended Dilution: WB: 1/1000
• Reactivities: Human, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: Recombinant protein of human Bag3
• Formulation: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: Calculated MW: 62 kDa; Observed MW: 80 kDa
• Gene Name: BCL2 associated athanogene 3
• Database Link:
  Entrez Gene 9531 Human
  UniProt ID O95817
• Background: Swiss-Prot Acc.O95817.Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:9873016, PubMed:27474739). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920).
• Synonyms: BAG-3; BIS; CAIR-1; MGC104307