IL18 Rabbit Monoclonal Antibody [Clone ID: R02-8B2]

CAT#: TA384518

IL-18 Rabbit monoclonal Antibody

Product Images

Western blot detection of IL18 in Hela cell lysates using IL18 Rabbit mAb(1:1000 diluted).Predicted band size:22kDa.Observed band size:17kDa.

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  Immunohistochemistry of IL-18 in paraffin-embedded Human colon cancer tissue using IL-18 Rabbit mAb at dilution 1/50

Specifications

Product Data

• Clone Name: R02-8B2
• Applications: IHC, WB
• Recommended Dilution: WB: 1/1000
  IHC: 1/200
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: Recombinant protein of human IL18
• Formulation: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: Calculated MW: 22 kDa; Observed MW: 17 kDa
• Gene Name: interleukin 18
• Database Link:
  Entrez Gene 3606 Human
  UniProt ID Q14116
• Background: Swiss-Prot Acc.Q14116.A proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses (Probable). Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators (PubMed:14528293, PubMed:25500532). Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells (Probable) (PubMed:10653850).
• Synonyms: Iboctadekin; IGIF; IL-1g; IL-18; IL1F4; interleukin-18; MGC12320