SH2D1A Rabbit Monoclonal Antibody [Clone ID: R09-5F6]

CAT#: TA385238

SH2D1A Rabbit monoclonal Antibody


USD 380.00

4 Weeks*

Size
    • 100 ul

Product Images

Other products for "SH2D1A"

Specifications

Product Data
Clone Name R09-5F6
Applications WB
Recommended Dilution WB: 1/1000-1/2000
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Monoclonal
Immunogen A synthetic peptide of human SH2D1A/SAP
Formulation 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration lot specific
Purification Affinity Purified
Conjugation Unconjugated
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Stability 1 year
Predicted Protein Size Calculated MW: 14 kDa; Observed MW: 14 kDa
Gene Name SH2 domain containing 1A
Background Swiss-Prot Acc.O60880.Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (PubMed:11806999). However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1 (PubMed:12458214). Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells . May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.
Synonyms DSHP; EBVS; FLJ18687; FLJ92177; IMD5; LYP; MTCP1; SAP; XLP; XLPD
Reference Data

{0} Product Review(s)

0 Product Review(s) Submit review

Be the first one to submit a review

Product Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.