Sonic Hedgehog (SHH) Rabbit Polyclonal Antibody

CAT#: TA385239

Sonic Hedgehog Rabbit polyclonal Antibody

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: IHC-p: 1/50-1/200
  WB: 1/500-1/2000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthesized peptide derived from human Shh
• Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
• Concentration: lot specific
• Purification: Affinity Chromatography
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: Observed MW (kDa):40
• Gene Name: sonic hedgehog
• Database Link:
  Entrez Gene 6469 Human
  UniProt ID Q15465
• Background: Swiss-Prot Acc.Q15465.Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity . Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN . Both activities occur in the reticulum endoplasmic . Once cleaved, ShhC is degraded in the endoplasmic reticulum .
• Synonyms: HHG-1; HHG1; HLP3; HPE3; MCOPCB5; SMMCI; TPT; TPTPS