TATA binding protein (TBP) Mouse Monoclonal Antibody [Clone ID: 10C1-4F6-4B7]

CAT#: TA385380

TATA Box Binding Protein (10C1) Mouse monoclonal Antibody

Product Images

Immunohistochemical analysis of paraffin-embedded Human Breast Carcinoma usingTBP/TATA Binding Protein Mouse mAb diluted at 1:200.

Specifications

Product Data

• Clone Name: 10C1-4F6-4B7
• Applications: IHC
• Recommended Dilution: IHC1/100-1/200
• Reactivities: Human, Mouse, Rat
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Purified recombinant protein expressed in E.coli.
• Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.03% Proclin 300, pH 7.3.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: 35-45kDa
• Gene Name: TATA-box binding protein
• Database Link:
  Entrez Gene 6908 Human
  UniProt ID P20226
• Background: Swiss-Prot Acc.P20226.General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID (PubMed:2374612, PubMed:2363050, PubMed:2194289, PubMed:9836642, PubMed:27193682). Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II (PubMed:2374612, PubMed:2363050, PubMed:2194289, PubMed:9836642, PubMed:27193682). Component of a BRF2-containing transcription factor complex that regulates transcription mediated by RNA polymerase III (PubMed:26638071). Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription (PubMed:15970593). The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA.
• Synonyms: GTF2D; GTF2D1; HDL4; SCA17; TFIID