POLR2A Rabbit Polyclonal Antibody

CAT#: TA392907

Rpb1 (phospho-S1619) polyclonal antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500~1:1000 IHC: 1:50~1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic phosphopeptide derived from human Rpb1 around the phosphorylation site of Serine 1619.
• Specificity: p-Rpb1 (S1619) polyclonal antibody detects endogenous levels of Rpb1 protein only when phosphorylated at Ser1619.
• Formulation: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Concentration: 1mg/ml
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
• Stability: 1 year
• Predicted Protein Size: ~ 280 kDa
• Gene Name: polymerase (RNA) II subunit A
• Database Link:
  Entrez Gene 5430 Human
  UniProt ID P24928
• Background: RPB1 is a subunit of RNA polymerase II which catalyses transcription of RNA from DNA. RPB1 forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template.
• Synonyms: DNA-directed RNA polymerase III largest subunit; DNA-directed RNA polymerase II subunit A; DNA-directed RNA polymerase II subunit RPB1; POLR2; POLR2A; RNA-directed RNA polymerase II subunit RPB1; RNA polymerase II subunit B1
• Note: For research use only, not for use in diagnostic procedure.