BIRC5 Mouse Monoclonal Antibody [Clone ID: OTI2D9]

CAT#: TA400024

Anti-BIRC5/Survivin mouse mAb, clone OTI2D9, Biotinylated

Product Images

HEK293T cells were transfected with pCMV6-ENTRY control (Lane 1) or pCMV6-ENTRY BIRC5 (Lane 2) plasmids for 48 hrs. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-BIRC5-biotin and Streptavidin-HRP.

Specifications

Product Data

• Clone Name: OTI2D9
• Applications: WB
• Recommended Dilution: WB: 1:1000
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Full length human recombinant protein of human BIRC5 (NP_001159) produced in HEK293T cell.
• Formulation: PBS (pH7.4) containing 50% glycerol, 0.1% BSA and 0.02% NaN3
• Concentration: 0.5 mg/ml
• Purification: Purified from cell culture supernatant by affinity chromatography
• Conjugation: Biotin
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 16.2 kDa
• Gene Name: baculoviral IAP repeat containing 5
• Database Link:
  NP_001159
  Entrez Gene 332 Human
  UniProt ID O15392
• Background: This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts are involved in the regulation of this gene's expression. At least four transcript variants encoding distinct isoforms have been found for this gene, but the full-length natures of only three of them have been determined.
• Synonyms: API4; EPR-1

Reference Data

• Protein Families: Druggable Genome, Stem cell - Pluripotency
• Protein Pathways: Colorectal cancer, Pathways in cancer