Isocitrate dehydrogenase (IDH1) Mouse Monoclonal Antibody [Clone ID: OTI2H9]
CAT#: TA500610
Anti-IDH1 (Isocitrate Dehydrogenase 1) mouse monoclonal antibody, clone OTI2H9 (formerly 2H9)
Size: 30 ul
Formulation: Carrier Free
Specifications
Product Data | |
Clone Name | OTI2H9 |
Applications | IF, WB |
Recommended Dilution | WB 1:2000, IHC 1:50, IF 1:100 |
Reactivities | Human, Mouse, Rat |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Full-length protein expressed in 293T cell transfected with human IDH1 expression vector |
Formulation | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
Concentration | 1 mg/ml |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 46.7 kDa |
Gene Name | isocitrate dehydrogenase (NADP(+)) 1 |
Database Link | |
Background | Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. |
Synonyms | HEL-216; HEL-S-26; IDCD; IDH; IDP; IDPC; PICD |
Reference Data | |
Protein Pathways | Citrate cycle (TCA cycle), Glutathione metabolism, Metabolic pathways |
Documents
Product Manuals |
FAQs |
Resources
Antibody Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
CF500610 | Carrier-free (BSA/glycerol-free) IDH1 mouse monoclonal antibody, clone OTI2H9 (formerly 2H9) |
USD 465.00 |
|
TA400008 | Anti-IDH1 mouse mAb, clone OTI2H9, Biotinylated |
USD 399.00 |
|
TA400009 | Anti-IDH1 mouse mAb, clone OTI2H9, HRP conjugated |
USD 399.00 |
|
TA400028 | Anti-IDH1 mouse mAb, clone OTI2H9, DyLight488 conjugated |
USD 399.00 |
|
TA500610S | Anti-IDH1 (Isocitrate Dehydrogenase 1) mouse monoclonal antibody, clone OTI2H9 (formerly 2H9) |
USD 159.00 |
|
TA600198 | IDH1 Capture mouse monoclonal antibody, ELISA and Luminex validated, clone OTI2H9 |
USD 379.00 |
|
TA700198 | IDH1 biotinylated detection antibody, ELISA and Luminex validated mouse monoclonal antibody, clone OTI2H9 |
USD 399.00 |
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