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Papillary renal cell carcinoma (PRCC) Rabbit Polyclonal Antibody
Other products for "PRCC"
Specifications
| Product Data | |
| Applications | ELISA, IHC, WB |
| Recommended Dilution | WB 1:5000~20000, IHC 1:150,ELISA 1:100-1:2000 |
| Reactivities | Human, Monkey, Mouse |
| Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | DNA immunization. This antibody is specific for the N Terminus Region of the target protein. |
| Formulation | 20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0 |
| Concentration | 1.14mg/ml |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Gene Name | proline rich mitotic checkpoint control factor |
| Database Link | |
| Background | In a subset of papillary renal cell carcinomas, a t(X;1)(p11;q21) chromosome translocation has been repeatedly reported and is thought to be the cause of the cancer. As a result of the translocation, the transcription factor TFE3 on the X chromosome becomes fused to the PRCC (papillary renal cell carcinoma translocation-associated) gene on chromosome 1. The fused gene results in the fusion of N-terminal proline-rich region of the protein encoded by this gene to the entire TFE3 protein. This protein has been shown to interact with the mitotic checkpoint protein MAD2B, which suggests that the dominant-negative effect of the fusion protein with TFE3 may lead to a mitotic checkpoint defect. |
| Synonyms | MGC4723; MGC17178; OTTHUMP00000038719; papillary renal cell carcinoma (translocation-associated); papillary renal cell carcinoma translocation-associated gene product; proline-rich protein PRCC; RCCP1; TPRC |
| Note | This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT |
| Reference Data | |
| Protein Families | Druggable Genome |
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