CHMP4C Rabbit Polyclonal Antibody

CAT#: TA890004

Rabbit polyclonal CHMP4C Antibody

Product Images

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CHMP4C (RC204802, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with Rabbit pol. Positive lysates LY407666 (100ug) and LC407666 (20ug) can be purchased separately from OriGene.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB 1:500, IHC 1:150
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide conjugated to KLH derived from C terminal of Human CHMP4C.
• Formulation: PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: Purified from the immunized serum by affinity chromatography (Protein A/G)
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 26.2 kDa
• Gene Name: charged multivesicular body protein 4C
• Database Link:
  NP_689497
  Entrez Gene 66371 MouseEntrez Gene 361916 RatEntrez Gene 92421 Human
  UniProt ID Q96CF2
• Background: CHMP4C belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]). [supplied by OMIM, Mar
• Synonyms: Shax3; SNF7-3; VPS32C

Reference Data

• Protein Pathways: Endocytosis