PMS2 Rabbit Polyclonal Antibody

CAT#: TA899002S

PMS2 Rabbit Polyclonal Antibody

Product Images

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PMS2 cDNA (Cat# RC210880, Right lane) for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PMS2(Cat# TA899002).(1:500)

Specifications

Product Data

• Applications: ELISA, WB
• Recommended Dilution: ELISA 1:5000-10000, WB 1:500
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: This antibody is raised against a recombinant protein of PMS2 expressed in HEK293 cells
• Formulation: Tissue culture buffer containing 1% BSA and 0.02% Sodium azide
• Concentration: Lot dependent; please refer to CoA along with shipment
• Purification: Purified from the immunized serum by affinity chromatography (Protein A/G)
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 95.8 kDa
• Gene Name: PMS1 homolog 2, mismatch repair system component
• Database Link:
  NP_000526
  Entrez Gene 5395 Human
  UniProt ID P54278
• Background: This gene is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2008]
• Synonyms: HNPCC4; MLH4; PMS2CL; PMSL2

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Mismatch repair