Azin1 (NM_018745) Mouse Untagged Clone

CAT#: MC205517

Azin1 (untagged) - Mouse antizyme inhibitor 1 (Azin1), transcript variant 2, (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Azin1
• Synonyms: 1700085L02Rik; AZI; Oazi; Oazin
• Vector: PCMV6-Kan/Neo
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >BC019412
  GGCTCAACTCTCGCCGCGGTGTTTCCGTTTTTCTCTCTGGTTGTCTCCTGCTCTGCTCTTCTCATCCTTC TCGCTCTGCTGCTCTGCGGAGTGACGAGGCTGAATCCTCTCCCCACCCAGTTCGCGCCTTTCTTCTTTTT CTCGCGCCGCTCCATTTCTCCAGTTCGGCTGCCGCCGCCACTGCTGCTCAGCTGGTGTCGGTGCCGCGCG TTTCCCCCACGTCGTCCCCGCAGCCTATGGCCCAGGCCGCCTTGGGTATTTCTGCTCAAGGTAACCACAT CCCTCTTTAAAAATTCCGCCGAAAAAGAGAAGACGCTTTACCCGACTCTTTGGGCCGTTATCTCACGGCG AACTTTCTGACCGAGTATACAACTACCCAGAAGGCCTAGGAGAAGTGCTGTATAGAGAGCAGTTCGACTT CAACGCTGAGCCACCTTGGGAACCTAGCTGATGATAGGGGGTTCCATCTCCTAACTTGTCCATTTTGTTG CATATTCTAAGGACCCAGACATAGGCTTGGTGGCCCGTCTCTTGTTTTTCCTGGTTTATGACTTTCGGCT TTGTGGAATACGGCTGAGATGAAAGGATTTATTGACGATGCGAACTACTCCGTTGGCCTGTTGGATGAAG GAACAAACCTTGGAAATGTTATTGATAACTATGTTTATGAACATACCCTGACAGAGAAAAATGCATTTTT TGTGGGGGATCTTGGGAAGATCGTGAAGAAGCACAGTCAGTGGCAGACCGTGGTGGCTCAGATAAAGCCG TTTTACACGGTGAAGTGCAACTCCACTCCAGCCGTGCTTGAGATCTTGGCAGCTCTTGGAACTGGGTTTG CTTGTTCCAGCAAAAATGAAATGGCTTTAGTGCAAGAATTGGGTGTATCTCCAGAAAACATCATTTTCAC AAGTCCTTGTAAGCAAGTGTCTCAGATAAAGTATGCAGCAAAAGTTGGAGTAAATATTATGACATGTGAC AATGAGATTGAATTAAAGAAAATTGCAAGGAATCACCCAAATGCCAAGGTCTTACTACATATTGCAACAG AAGATAATATTGGAGGTGAAGATGGTAACATGAAGTTTGGCACTACACTGAAGAATTGTAGGCATCTTTT GGAATGTGCCAAGGAACTTGATGTCCAAATAATTGGGGTTAAATTTCATGTTTCAAGTGCTTGCAAAGAA TATCAAGTATATGTACATGCCCTGTCTGATGCTCGATGTGTGTTTGACATGGCTGGAGAGTTTGGCTTTA CAATGAACATGTTAGACATCGGTGGAGGCTTCACAGGAACTGAAATTCAGTTGGAAGAGGTTAATCATGT TATCAGTCCTCTGTTGGATATTTACTTCCCTGAAGGATCTGGCATTCAGATAATTTCAGAACCTGGAAGC TACTATGTATCTTCTGCGTTTACACTTGCAGTCAATATTATTGCTAAGAAAGTTGTTGAAAATGATAAAT TTTCCTCTGGAGTAGAAAAAAATGGGAGTGATGAGCCAGCCTTCGTGTATTACATGAATGATGGTGTTTA TGGTTCTTTTGCGAGTAAGCTTTCTGAGGACTTAAATACCATTCCAGAGGTTCACAAGAAATACAAGGAA GATGAGCCTCTGTTTACAAGCAGCCTTTGGGGTCCATCCTGTGATGAGCTTGATCAAATTGTGGAAAGCT GTCTTCTTCCTGAGCTGAATGTGGGAGATTGGCTTATCTTTGATAACATGGGAGCAGATTCTTTCCACGA ACCATCTGCTTTTAATGATTTTCAGAGGCCAGCTATTTATTTCATGATGTCATTCAGTGATTGGTATGAG ATGCAAGATGCTGGAATTACTTCAGATGCAATGATGAAAAACTTCTTCTTTGCACCCTCTTGTATTCAGC TGAGCCAAGAAGACAGCTTTTCCACTGAAGCTTAAACAGGCATTAACGCTTCCTTAGATCTGAAGTCGCA GGTTAAGCTTGTCTGGTCTACATTCCAGTGTGGGGGGAAAAAAATCAATCTTTATTCTGTTAATTTCTTG GAAACAAATTCATAGTAATAGCTATTTGGGACCAGACAAAATCAGCTTTCATCTATAATTCATTGGGGGT AATAGGGGATTTAGATAATGTATCCAGAGTTAAACATACCAGTTTGACCCACCCCTTAAGCGTTTAAAAT AAAATATGCAACAAAATGGATGACTTAGTGGAGATGGAAGCCCATTAACTGGGTTCCCCATCAAATCGTT TACATACAAGTACACAGTTTTTATAAGGATTCCTGTTAAAAGTCTTGTAAAGTTGATGTCTTTCACCCAG ATATATCACATGTGAGTGGAAGACCAGTGTGACTTCATTAGATACGTTTAGTGTATTTAGGATGTGTAAA TTTGTGCTTTTGAACTGTAGTTTAATAAATGTAAAATTGCATCATAGTATTTGTTGTATTTGACCTAATG TAACCCTTGTATGATTGCAATAAAACTTTGTGTAGATCTTAAAAAAAAAAAAAAAAA
• Restriction Sites: RsrII-NotI
• ACCN: NM_018745
• ORF Size: 1347 bp
• Insert Size: 1347
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: BC019412, AAH19412
• RefSeq Size: 2507
• RefSeq ORF: 1347
• Locus ID: 54375
• Gene Summary: The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. RNA editing of this gene, predominantly in the liver tissue, has been linked to the progression of hepatocellular carcinoma. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2014]
  Transcript Variant: This variant (2) lacks an internal 5' non-coding exon, thus has a shorter 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments.