SP140 (NM_007237) Human Tagged ORF Clone

CAT#: RC222828L4

Lenti-ORF clone of SP140 (mGFP-tagged)-Human SP140 nuclear body protein (SP140), transcript variant 1

Specifications

Product Data

• Type: Human Tagged ORF Clone
• Tag: mGFP
• Symbol: SP140
• Synonyms: LYSP100; LYSP100-A; LYSP100-B
• Vector: pLenti-C-mGFP-P2A-Puro
• E. coli Selection: Chloramphenicol (34 ug/mL)
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC222828).
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene
• ACCN: NM_007237
• ORF Size: 2601 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_007237.3, NP_009168.3
• RefSeq Size: 3269
• RefSeq ORF: 2604
• Locus ID: 11262
• Domains: SAND, BROMO, PHD, Sp100
• Protein Families: Druggable Genome, Transcription Factors
• MW: 98 kDa
• Gene Summary: This gene encodes a member of the SP100 family of proteins, which are share common domains including an N-terminal homogeneously staining region domain followed by a SP100/autoimmune regulator/NucP41/P75/deformed epidermal autoregulatory factor domain, a plant homeobox zinc finger, and a bromodomain. The encoded protein is interferon-inducible and is expressed at high levels in the nuclei of leukocytes. Variants of this gene have been associated with multiple sclerosis, Crohn's disease, and chronic lymphocytic leukemia. Alternative splicing results in multiple variants. [provided by RefSeq, Aug 2016]