SLC22A17 (NM_001289050) Human Tagged ORF Clone

CAT#: RC237317

SLC22A17 (myc-DDK-tagged) - Human solute carrier family 22, member 17 (SLC22A17), transcript variant 3

Specifications

Product Data

• Type: Human Tagged ORF Clone
• Tag: Myc-DDK
• Symbol: SLC22A17
• Synonyms: 24p3R; BOCT; BOIT; hBOIT; NGALR; NGALR2; NGALR3
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  ORF Nucleotide Sequence

  >RC237317 representing NM_001289050
  Red=Cloning site Blue=ORF Green=Tags(s)
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGATCACCGCTCCCTGCATCCTCTTCCTGTTTTATGGCTGGCCTGGTTTGTTCCTGGAGTCCGCACGGT
  GGCTGATAGTGAAGCGGCAGATTGAGGAGGCTCAGTCTGTGCTGAGGATCCTGGCTGAGCGAAACCGGCC
  CCATGGGCAGATGCTGGGGGAGGAGGCCCAGGAGGCCCTGCAGGACCTGGAGAATACCTGCCCTCTCCCT
  GCAACATCCTCCTTTTCCTTTGCTTCCCTCCTCAACTACCGCAACATCTGGAAAAATCTGCTTATCCTGG
  GCTTCACCAACTTCATTGCCCATGCCATTCGCCACTGCTACCAGCCTGTGGGAGGAGGAGGGAGCCCATC
  GGACTTCTACCTGTGCTCTCTGCTGGCCAGCGGCACCGCAGCCCTGGCCTGTGTCTTCCTGGGGGTCACC
  GTGGACCGATTTGGCCGCCGGGGCATCCTTCTTCTCTCCATGACCCTTACCGGCATTGCTTCCCTGGTCC
  TGCTGGGCCTGTGGGATTATCTGAACGAGGCTGCCATCACCACTTTCTCTGTCCTTGGGCTCTTCTCCTC
  CCAAGCTGCCGCCATCCTCAGCACCCTCCTTGCTGCTGAGGTCATCCCCACCACTGTCCGGGGCCGTGGC
  CTGGGCCTGATCATGGCTCTAGGGGCGCTTGGAGGACTGAGCGGCCCGGCCCAGCGCCTCCACATGGGCC
  ATGGAGCCTTCCTGCAGCACGTGGTGCTGGCGGCCTGCGCCCTCCTCTGCATTCTCAGCATTATGCTGCT
  GCCGGAGACCAAGCGCAAGCTCCTGCCCGAGGTGCTCCGGGACGGGGAGCTGTGTCGCCGGCCTTCCCTG
  CTGCGGCAGCCACCCCCTACCCGCTGTGACCACGTCCCGCTGCTTGCCACCCCCAACCCTGCCCTC
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
  Protein Sequence

  >RC237317 representing NM_001289050
  Red=Cloning site Green=Tags(s)
  
  MITAPCILFLFYGWPGLFLESARWLIVKRQIEEAQSVLRILAERNRPHGQMLGEEAQEALQDLENTCPLP
  ATSSFSFASLLNYRNIWKNLLILGFTNFIAHAIRHCYQPVGGGGSPSDFYLCSLLASGTAALACVFLGVT
  VDRFGRRGILLLSMTLTGIASLVLLGLWDYLNEAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRG
  LGLIMALGALGGLSGPAQRLHMGHGAFLQHVVLAACALLCILSIMLLPETKRKLLPEVLRDGELCRRPSL
  LRQPPPTRCDHVPLLATPNPAL
  
  TRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene Plasmid Map
• ACCN: NM_001289050
• ORF Size: 906 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_001289050.1, NP_001275979.1
• RefSeq Size: 2027
• RefSeq ORF: 909
• Locus ID: 51310
• Protein Families: Druggable Genome, Transmembrane
• MW: 33.1 kDa
• Gene Summary: Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis. [UniProtKB/Swiss-Prot Function]