LAT2 (SLC7A8) (NM_182728) Human Untagged Clone

CAT#: SC107507

SLC7A8 (untagged)-Human solute carrier family 7 (amino acid transporter, L-type), member 8 (SLC7A8), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: SLC7A8
• Synonyms: LAT2; LPI-PC1
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC107507 sequence for NM_182728 edited (data generated by NextGen Sequencing)
  ATGGGGATTGTACAGATATGCAAAGGAGAGTACTTCTGGCTGGAGCCAAAGAATGCATTT
  GAGAATTTCCAGGAACCTGACATCGGCCTCGTCGCACTGGCTTTCCTTCAGGGCTCCTTT
  GCCTATGGAGGCTGGAACTTTCTGAATTACGTGACTGAGGAGCTTGTTGATCCCTACAAG
  AACCTTCCCAGAGCCATCTTCATCTCCATCCCACTGGTCACATTTGTGTATGTCTTTGCC
  AATGTCGCTTATGTCACTGCAATGTCCCCCCAGGAGCTGCTGGCATCCAACGCCGTCGCT
  GTGACTTTTGGAGAGAAGCTCCTAGGAGTCATGGCCTGGATCATGCCCATTTCTGTTGCC
  CTGTCCACATTTGGAGGAGTTAATGGGTCTCTCTTCACCTCCTCTCGGCTGTTCTTCGCT
  GGAGCCCGAGAGGGCCACCTTCCCAGTGTGTTGGCCATGATCCACGTGAAGCGCTGCACC
  CCAATCCCAGCCCTGCTCTTCACATGCATCTCCACCCTGCTGATGCTGGTCACCAGCGAC
  ATGTACACACTCATCAACTACGTGGGCTTCATCAACTACCTCTTCTATGGGGTCACGGTT
  GCTGGACAGATAGTCCTTCGCTGGAAGAAGCCTGATATCCCCCGCCCCATCAAGATCAAC
  CTGCTGTTCCCCATCATCTACTTGCTGTTCTGGGCCTTCCTGCTGGTCTTCAGCCTGTGG
  TCAGAGCCGGTGGTGTGTGGCATTGGCCTGGCCATCATGCTGACAGGAGTGCCTGTCTAT
  TTCCTGGGTGTTTACTGGCAACACAAGCCCAAGTGTTTCAGTGACTTCATTGAGCTGCTA
  ACCCTGGTGAGCCAGAAGATGTGTGTGGTCGTGTACCCCGAGGTGGAGCGGGGCTCAGGG
  ACAGAGGAGGCTAATGAGGACATGGAGGAGCAGCAGCAGCCCATGTACCAACCCACTCCC
  ACGAAGGACAAGGACGTGGCGGGGCAGCCCCAGCCCTGA
  
  Clone variation with respect to NM_182728.1
  561 t=>c
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_182728 unedited
  TTTTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGATTGCTCCTCACA
  TGGGTCAACTGTTCCAGTGTGCGGTGGGCCACCCGGGTTCAAGACATCTTCACAGCTGGG
  AAGCTCCTGGCCTTGGCCCTGATTATCATCATGGGGATTGTACAGATATGCAAAGGAGAG
  TACTTCTGGCTGGAGCCAAAGAATGCATTTGAGAATTTCCAGGAACCTGACATCGGCCTC
  GTCGCACTGGCTTTCCTTCAGGGCTCCTTTGCCTATGGAGGCTGGAACTTTCTGAATTAC
  GTGACTGAGGAGCTTGTTGATCCCTACAAGAACCTTCCCAGAGCCATCTTCATCTCCATC
  CCACTGGTCACATTTGTGTATGTCTTTGCCAATGTCGCTTATGTCACTGCAATGTCCCCC
  CAGGAGCTGCTGGCATCCAACGCCGTCGCTGTGACTTTTGGAGAGAAGCTCCTAGGAGTC
  ATGGCCTGGATCATGCCCATTTCTGTTGCCCTGTCCACATTTGGAGGAGTTAATGGGTCT
  CTCTTCACCTCCTCTCGGCTGTTCTTCGCTGGAGCCCGAGAGGGCCACCTTCCCAGTGTG
  TTGGCCATGATCCACGTGAAGCGCTGCACCCCAATCCCAGCCCTGCTCTTCACATGCATC
  TCCACCCTGCTGATGCTGGTCACCAGCGACATGTACACACTCATCAACTACGTGGGCTTC
  ATCAACTACCTCTTCTATGGGGTCACGGTTGCTGGACAGAAGTCCTTCGCTGGAAGAACC
  TGATATCCCCGCCCCATCAGATCACCTGCTNGTCCCATCACTACTTGCTGTCTGGGCCTT
  CTGCTGTCTTCACCTGGGTCAAACCCGTGGTGTGTGCATT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_182728
• ORF Size: 999 bp
• Insert Size: 3000
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_182728.1, NP_877392.1
• RefSeq Size: 3145
• RefSeq ORF: 999
• Locus ID: 23428
• Protein Families: Druggable Genome, Transmembrane
• Gene Summary: Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney. [UniProtKB/Swiss-Prot Function]
  Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a.