PLAT (NM_033011) Human Untagged Clone

CAT#: SC109578

PLAT (untagged)-Human plasminogen activator, tissue (PLAT), transcript variant 3


  "NM_033011" in other vectors (6)

Reconstitution Protocol

USD 760.00

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol PLAT
Synonyms T-PA; TPA
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene sequence for NM_033011 edited
GAATTCGGCACGAGGCAGGAGTCCAGGGCTGGAGAGAAAACCTCTGCGAGGAAAGGGAAG
GAGCAAGCCGTGAATTTAAGGGACGCTGTGAAGCAATCATGGATGCAATGAAGAGAGGGC
TCTGCTGTGTGCTGCTGCTGTGTGGAGCAGTCTTCGTTTCGCCCAGCCAGGAAATCCATG
CCCGATTCAGAAGAGGAGCCAGATCTTACCAAGGTTGCAGCGAGCCAAGGTGTTTCAACG
GGGGCACCTGCCAGCAGGCCCTGTACTTCTCAGATTTCGTGTGCCAGTGCCCCGAAGGAT
TTGCTGGGAAGTGCTGTGAAATAGATACCAGGGCCACGTGCTACGAGGACCAGGGCATCA
GCTACAGGGGCACGTGGAGCACAGCGGAGAGTGGCGCCGAGTGCACCAACTGGAACAGCA
GCGCGTTGGCCCAGAAGCCCTACAGCGGGCGGAGGCCAGATGCCATCAGGCTGGGCCTGG
GGAACCACAACTACTGCAGAAACCCAGATCGAGACTCAAAGCCCTGGTGCTACGTCTTTA
AGGCGGGGAAGTACAGCTCAGAGTTCTGCAGCACCCCTGCCTGCTCTGAGGGAAACAGTG
ACTGCTACTTTGGGAATGGGTCAGCCTACCGTGGCACGCACAGCCTCACCGAGTCGGGTG
CCTCCTGCCTCCCGTGGAATTCCATGATCCTGATAGGCAAGGTTTACACAGCACAGAACC
CCAGTGCCCAGGCACTGGGCCTGGGCAAACATAATTACTGCCGGAATCCTGATGGGGATG
CCAAGCCCTGGTGCCACGTGCTGAAGAACCGCAGGCTGACGTGGGAGTACTGTGATGTGC
CCTCCTGCTCCACCTGCGGCCTGAGACAGTACAGCCAGCCTCAGTTTCGCATCAAAGGAG
GGCTCTTCGCCGACATCGCCTCCCACCCCTGGCAGGCTGCCATCTTTGCCAAGCACAGGA
GGTCGCCCGGAGAGCGGTTCCTGTGCGGGGGCATACTCATCAGCTCCTGCTGGATTCTCT
CTGCCGCCCACTGCTTCCAGGAGAGGTTTCCGCCCCACCACCTGACGGTGATCTTGGGCA
GAACATACCGGGTGGTCCCTGGCGAGGAGGAGCAGAAATTTGAAGTCGAAAAATACATTG
TCCATAAGGAATTCGATGATGACACTTACGACAATGACATTGCGCTGCTGCAGCTGAAAT
CGGATTCGTCCCGCTGTGCCCAGGAGAGCAGCGTGGTCCGCACTGTGTGCCTTCCCCCGG
CGGACCTGCAGCTGCCGGACTGGACGGAGTGTGAGCTCTCCGGCTACGGCAAGCATGAGG
CCTTGTCTCCTTTCTATTCGGAGCGGCTGAAGGAGGCTCATGTCAGACTGTACCCATCCA
GCCGCTGCACATCACAACATTTACTTAACAGAACAGTCACCGACAACATGCTGTGTGCTG
GAGACACTCGGAGCGGCGGGCCCCAGGCAAACTTGCACGACGCCTGCCAGGGCGATTCGG
GAGGCCCCCTGGTGTGTCTGAACGATGGCCGCATGACTTTGGTGGGCATCATCAGCTGGG
GCCTGGGCTGTGGACAGAAGGATGTCCCGGGTGTGTACACCAAGGTTACCAACTACCTAG
ACTGGATTCGTGACAACATGCGACCGTGCCCAGGAACACCCGACTCCTCAAAAGCAAATG
AGATCCCGCCTCTTCTTCTTCAGAAGACACTGCAAAGGCGCAGTGCTTCTCTACAGACTT
CTCCAGACCCACCACACCGCAGAAGCGGGACGAGACCCTACAGGAGAGGGAAGAGTGCAT
TTTCCCAGATACTTCCCATTTTGGAAGTTTTCAGGACTTGGTCTGATTTCAGGATACTCT
GTCAGATGGGAAGACATGAATGCACACTAGCCTCTCCAGGAATGCCTCCTCCCTGGGCAG
AAAGTGGCCATGCCACCCTGTTTTCAGCTAAAGCCCAACCTCCTGACCTGTCACCGTGAG
CAGCTTTGGAAACAGGACCACAAAAATGAAAGCATGTCTCAATAGTAAAAGATAACAAGA
TCTTTCAGGAAAGACGGATTGCATTAGAAATAGACAGTATATTTATAGTCACAAGAGCCC
AGCAGGGCCTCAAAGTTGGGGCAGGCTGGCTGGCCCGTCATGTTCCTCAAAAGCACCCTT
GACGTCAAGTCTCCTTCCCCTTTCCCCACTCCCTGGCTCTCAGAAGGTATTCCTTTTGTG
TACAGTGTGTAAAGTGTAAATCCTTTTTCTTTATAAACTTTAGAGTAGCATGAGAGAATT
GTATCATTTGAACAACTAGGCTTCAGCATATTTATAGCAATCCATGTTAGTTTTTACTTT
CTGTTGCCACAACCCTGTTTTATACTGTACTTAATAAATTCAGATATATTTTTCACAGTT
TTTCCAAAAAAAAAAAAAAAAAACTCGAC
>OriGene 5' read for NM_033011 unedited
AAAAACCTTCGGCACGAGGCAGGAGTCCATTGCTGGAGAGAAAACCTCTGCGAGGAAAGG
GAAGGAGCAAGCCGTGAATTTAAGGGACGCTGTGAAGCAATCATGGATGCAATGAAGAGA
GGGCTCTGCTGTGTGCTGCTGCTGTGTGGAGCAGTCTTCGTTTCGCCCAGCCAGGAAATC
CCCTCCCGATTCAGAAGATGAGCCTGATCTTACCAAGGTTGCAGCGAGCCAAGGTGTTTC
AACGGGGGCACCTGCCAGCAGGCCCTGTACTTCTCAGATTTCGTGTGCCAGTGCCCCGAA
GGATTTGCTGGGAAGTGCTGTGAAATAGATACCAGGGCCACGTGCTACGAGGACCAGGGC
ATCAGCTACAGGGGCACGTGGAGCACAGCGGAGAGTGGCGCCGAGTGCACCAACTGGAAC
AGCAGCGCGTTGGCCCAGAAGCCCTACAGCGGGCGGAGGCCAGATGCCATCAGGCTGGGC
CTGGGGAACCACAACTACTGCAGAAACCCAGATCGAGACTCAAAGCCCTGGTGCTACGTC
TTTAATGCGGGGAAGTACAGCTCAGAGTTCTGCAGCACCCCTGCCTGCTCTGAGGGAAAC
AGTGACTGCTACTTTGGGAATGGGTCAGCCTACCGTGGCACGCACAGCCCTCCCGAGTCG
GGTGCCTCCTGGCTCCCGTGGAATTCCCTGATCCTGATAGGCATTGTTTACACAGCACAG
AACCCCAGTGCCCATGCACTTGGGCCTGGGGCAACCTAATTACTGGCCGGATTCCTGGTG
GGGATGGCCCAGCCCTGGTGCCACTTGCTGGAATACCCGCGGCTGGACGTGGGAGGTCCT
GGGATGGGCCCTCCTGCTCTCCCTGGGGGCCGGGGACAGTCCAGCCAGCCTCATTTTTCA
TAA
>OriGene 3' read for NM_033011 unedited
NNTTTTAGCTATGNACCCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTGG
AAAAACTGTGAAAAATATATCTGAATTTATTAAGTACAGTATAAAACAGGGTTGTGGCAA
CAGAAAGTAAAAACTAACATGGATTGCTATAAATATGCTGAAGCCTAGTTGTTCAAATGA
TACAATTCTCTCATGCTACTCTAAAGTTTATAAAGAAAAAGGATTTACACTTTACACACT
GTACACAAAAGGAATACCTTCTGAGAGCCAGGGAGTGGGGAAAGGGGAAGGAGACTTGAC
GTCAAGGGTGCTTTTGAGGAACATGACGGGCCAGCCAGCCTGCCCCAACTTTGAGGCCCT
GCTGGGCTCTTGTGACTATAAATATACTGTCTATTTCTAATGCAATCCGTCTTTCCTGAA
AGATCTTGTTATCTTTTACTATTGAGACATGCTTTCATTTTTGTGGTCCTGTTTCCAAAG
CTGCTCACGGTGACAGGTCAGGAGGTTGGGCTTTAGCTGAAAACAGGGTGGCATGGCCAC
TTTCTGCCCAGGGAGGAGGCATTCCTGGAGAGGCTAGTGTGCATTCATGTCTTCCCATCT
GACAGAGTATCCTGAAATCAGACCAAGTCCTGAAAACTTCCAAAATGGGAAGTATCTGGG
AAAATGCACTCTTCCCTCTCCTGTAGGGTCTCGTCCCGCTTCTGNCGTGTGGTGGGTCTG
GAGAAGTCTGTAAAGAGCACTGCGCCTTTGCAGTGTCTTCTGAAGAAGAAGAGGCGGATC
TCATTTGCTTTTTGAGAGTCGGGTGTTTCTGGGCACGGTCGCATGNTGTCACGAATCCAG
TCTAGGTAGTTGGGTACCCTGGTGTACACACCCGGNACATNCTTNTGTCCACANCCCCAG
CCCAGCTGT
Restriction Sites NotI-NotI     
ACCN NM_033011
Insert Size 2700 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_033011.1, NP_127509.1
RefSeq Size 2534 bp
RefSeq ORF 1551 bp
Locus ID 5327
Cytogenetics 8p11.21
Domains KR, Tryp_SPc, EGF
Protein Families Druggable Genome, Protease, Secreted Protein
Protein Pathways Complement and coagulation cascades
Gene Summary 'This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]'
Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1. This isoform (3) may undergo proteolytic processing similar to isoform 1.

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